Abstract
A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.
MeSH terms
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Animals
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Ataxia / chemically induced
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Behavior, Animal / drug effects*
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Chemical Phenomena
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Chemistry
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Isoquinolines / chemical synthesis
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Isoquinolines / metabolism
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Isoquinolines / pharmacology*
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Male
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Molecular Structure
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Phenazocine / analogs & derivatives
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Phenazocine / metabolism
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Phencyclidine / analogs & derivatives
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Phencyclidine / metabolism
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Phencyclidine / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, Neurotransmitter / metabolism
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Receptors, Phencyclidine
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Stereotyped Behavior / drug effects
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Structure-Activity Relationship
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Tetrahydroisoquinolines*
Substances
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Isoquinolines
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Receptors, Neurotransmitter
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Receptors, Phencyclidine
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Tetrahydroisoquinolines
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1,2,3,4-tetrahydroisoquinoline
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SK&F 10047
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tenocyclidine
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Phenazocine
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Phencyclidine